We provided full industrial design and engineering services to create a next generation ultrasound-based organ and tumor location cart system that is smaller, significantly lighter, and easier to maneuver than its predecessor. A unique foot pedal activated stabilizing system, two-way keyboard tray, easy-to-access storage compartments, and a rotating touch display allow for operation on both sides of the cart in tight quarters. In addition to answering the needs of the cart user, the design better integrates the appearance with the new corporate identity established by our client. The original cart was introduced in 1998 and it has become a successful ancillary treatment device, used in approximately 100 hospitals nationwide. Though originally developed to localize prostate tumors, this cart is considered a valuable tool for many kinds of radiation treatment, including cancers of the breast, bladder, liver, pancreas, cervix, head, and neck.